Best Disease is a genetic condition that affects the macula causing central vision loss. This condition is often diagnosed in asymptomatic patients who have a yellow spot in the center of the retina. When symptoms develop they often include misperception of colors and details. It is a bilateral disease but the progression of the disease varies from eye to eye. The characteristic yellow lesion is an accumulation of lipofuscin under the retinal pigment epithelium (RPE), a layer under the retina. Overtime, the lesion will become a scar with signs of central macular atrophy. See the information document in this section for further details.