The Retina Reference

Time Domain OCT in Hydroxychloroquine (Plaquenil) Toxicity

Time domain OCT does not have the resolution that spectral domain OCT has, making detection of hydroxychloroquine maculopathy by this modality less sensitive. Nevertheless, time domain OCT machines are more widely available, making it important to be able to recognize toxicity with this test. In this image, the perifoveal inner segment-outer segment junction has been lost (at the purple arrows). The junction remains in the fovea (white arrow). When this thinning is translated into an OCT map, a bulls-eye pattern of thinning is manifested, as shown in the image entitled "Time Domain OCT Map in Hydroxychloroquine Toxicity". The patient shown here is the same one shown in the image "Asymmetric Hydroxychloroquine (Plaquenil) Retinal Toxicity".