The Retina Reference

Time Domain OCT Map in Hydroxychloroquine Toxicity

The time domain OCT map in a case of hydroxychloroquine toxicity shows pericentral thinning of the macula. In the false color map, this appears as a bulls-eye with a red annulus of thinned retina surrounding the fovea. In this case, a bulls-eye pattern is present in the left eye, even though the fundus photograph and fluorescein angiogram showed no bulls-eye pigmentary alteration (the case shown here is the same as in the image "Asymmetric Hydroxychloroquine (Plaquenil) Retinal Toxicity"). That is, in this case, time domain OCT was more sensitive than fundus photography or fluorescein angiography in the detection of maculopathy. It is common to do several tests to aid in early detection of macular toxicity, including perimetry, fundus autofluorescence, multifocal electroretinography, and OCT.