The Retina Reference

Retinitis Pigmentosa - Presentation through Fundus Autofluorescence

Fundus autofluorescence images of a patient with severe retinitis pigmentosa. The yellow arrows in both frames show hyperautofluorescence of lipofusicin, a metabolic byproduct of the breakdown of photoreceptor outer segments by the retinal pigment epithelium. The large black spots, indicated by the red arrows ,are areas of complete cellular drop out with no function. Eventually, the hyperfluorescence shown by the yellow arrows will progress to be like the larger black spots, resulting in greater visual loss.