Interferon-Associated Retinopathy

These fundus photographs from a 57 year old woman with hepatitis C treated with intravenous interferon alpha show cotton wool spots in a peripapillary distribution. She had no other causes for cotton wool spots such as human immunodeficiency virus infection or Purtscher's retinopathy associated with trauma. Therefore, a diagnosis of interferon-associated retinopathy was made. Visual acuity was unaffected, therapy was continued, and the cotton wool spots eventually resolved.