Hydroxychloroquine Retinopathy-Fundus Autofluorescence

Fundus autofluorescence image of a 46-year-old woman with systemic lupus erythematosus who had taken chloroquine for 17 years at a dosage of 500 mg/d. Based on her actual body weight, which was ideal, she had been overdosed at 8.8 mg/kg/d and had received a cumulative dose of 3102 g of hydroxychloroquine. The preferential damage to the inferior paramacula is shown with the incomplete RPE atrophic annulus (yellow arrow). The superior paramacula from ten to one o'clock is spared (blue arrow).The inferior midperipheral atrophic zone is more pronounced than the superior (red arrows).